Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice

doi:10.1211/jpp.60.2.0013

CNU IR > Pharmacy and Science > Dept. of Food Science & Technology > Periodical Articles > Item 310902800/21577

Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/21577

Title:	Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice
Authors:	Lisu Wang Choi-Lan Ha Tso-Lin Cheng Su-Yun Cheng Tzi-Wei Lian Ming-Jiuan Wu
Contributors:	食品科技系保健營養系生物科技系
Date:	2008-02
Issue Date:	2009-07-21 14:07:10 (UTC+8)
Publisher:	Pharmaceutical Press-Royal Pharmaceutical Soc Great Britian
Abstract:	Grifola frondosa fruiting body (Maitake) has been used as a dietary supplement due to its antitumour and immunomodulatory properties. The aim of this study was to evaluate the immunomodulatory effects of orally administered submerged cultivated G. frondosa mixture, including both mycelium and culture broth, in a healthy murine model. Composition analyses showed that submerged cultivated G. frondosa mixture contained only 32.48% carbohydrate, which was less than half of fruiting bodies. The content of adenosine, a potential immunomodulatory agent in medicinal mushrooms, was 2.8 mg g−1. After feeding 8-week-old female BALB/cByJ mice with AIN-93G diet containing 0% (C), 1% (G1), 3% (G3) or 5% (G5) (wt/wt) G. frondosa mixture for 31 days, neither body weight nor the outward appearance of organs showed any significant difference among different diet groups. Splenocyte subpopulation, mitogen-activated cytokine release and splenic NK activity were not affected by G. frondosa administration, either. On the other hand, the phagocytic activity was enhanced in leucocytes of groups G3 and G5, without exerting detectable levels of serum proinflammatory cytokines. These results suggested that oral administration of submerged cultivated G. frondosa mixture may enhance host innate immunity against foreign pathogens without eliciting adverse inflammatory response
Relation:	Journal of pharmacy and pharmacology 60(2)：p.237-243
Appears in Collections:	[Dept. of Food Science & Technology] Periodical Articles [Dept. of Health and Nutrition (including master's program)] Periodical Articles [Dept. of Biotechnology (including master's program)] Periodical Articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	1467	View/Open

Loading...