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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/21563


    標題: Extracts from Cladiella australis, Clavularia viridis and Klyxum simplex (Soft Corals) are Capable of Inhibiting the Growth of Human Oral Squamous Cell Carcinoma Cells
    作者: Chia-Hua Liang
    Guey-Horng Wang
    Chih-Chuang Liaw
    Mei-Feng Lee
    Shih-Hao Wang
    Da-Long Cheng
    Tzung-Han Chou
    梁家華
    貢獻者: 化粧品應用與管理系
    關鍵字: Soft corals
    Cladiella australis
    Clavularia viridis
    Klyxum simplex
    Apoptosis
    日期: 2008-11
    上傳時間: 2009-07-20 11:08:24 (UTC+8)
    摘要: Many biomedical products have already been obtained from marine organisms. In order to search more therapeutic drugs against cancer, this study demonstrates the cytotoxicity effects of Cladiella australis, Clavularia viridis and Klyxum simplex extracts on human oral squamous cell carcinoma (SCC4, SCC9 and SCC25) cells using cell adhesion and cell viability assay. The morphological alterations in SCCs cells after treatment with three extracts, such as typical nuclear condensation, nuclear fragmentation and apoptotic bodies of cells were demonstrated by Hoechst stain. Flow cytometry
    indicated that three extracts sensitized SCC25 cells in the G0/G1 and S-G2/M phases with a concomitant significantly increased sub-G1 fraction, indicating cell death by apoptosis. This apoptosis process was accompanied by activation of caspase-3 expression after SCC25 cells were treated with three extracts. Thereby, it is possible that extracts of C. australis, C. viridis and K. simplex cause apoptosis of SCCs and warrant further research investigating the possible anti-oral cancer compounds in these soft corals.
    關聯: Marine drugs 6(4):p.595-606
    Appears in Collections:[化妝品應用與管理系(所)] 期刊論文

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