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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/21560


    標題: Simultaneous Identification of Eight Sunscreen Compounds in Cosmetic Products Using high performance liquid chromatography and capillary electrophoresis
    作者: Lih-Jeng Juang
    Bor-Sen Wang
    Huo-Mu Tai
    Wei-Jing Hung
    Ming-Hsing Huang
    莊麗貞
    王柏森
    戴火木
    洪偉章
    黃明星
    貢獻者: 經國管理學院化妝品應用系
    食品科技系
    醫藥化學系
    化粧品應用與管理系
    關鍵字: sunscreen
    benzophenones
    high-performance liquid chromatography
    capillary electrophoresis
    日期: 2008-12
    上傳時間: 2009-07-20 11:08:18 (UTC+8)
    摘要: p-Aminobenzoates (PABA) and benzophenones in cosmetic products absorb UV radiation. We have developed two simple methods to simultaneously determine whether cosmetic products contain any of eight sunscreen compounds. The first method used high-performance liquid chromatography (HPLC) and a Cosmosil 5C18-MS column with an isocratic system consisting of acetonitrile-H2O solution (60/40, v/v) acidified by 0.1% phosphoric acid (v/v); the analysis was monitored by absorbance at 254 nm with a constant flow-rate 0.8 mL/min. This method could easily determine the presence of these compounds in non-pretreated sunscreen products in 30 min. The second method employed capillary electrophoresis (CE) in buffer solution (pH 10.0) containing 20 mM borate; the same analysis was made within 10 min. Reproducibility (relative standard deviation) of the proposed methods, on the basis of the peak-area ratios in six replicate injections, was good with only a slight deviation of 0.31 - 0.75% (for HPLC system) and 1.65 - 3.55% (for CE system). The detection limit (S/N = 3) of the individual marker substances varied from 0.08 to 0.87 μg/mL (for HPLC system) and 0.23 to 1.86 μg/mL (for CE system). Although the HPLC method was superior to the CE method in both reproducibility and resolution, it required longer retention time. The HPLC and CE methods developed were both successfully applied to the assay of 8 UV-absorbing agents in 11 commercial sun protection products.
    關聯: Journal of food and drug analysis 16(6):p.22-28
    Appears in Collections:[醫藥化學系 ] 期刊論文
    [化妝品應用與管理系(所)] 期刊論文
    [ 食品科技系 ] 期刊論文

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