Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/21556
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    標題: Urinary excretion of toluene diisocyanates in rats following dermal exposure
    作者: Hui-Jung Yeh
    Wei-Chao Lin
    Tung-Sheng Shih
    Perng-Jy Tsai
    Shan-Tair Wang
    Ho-Yuan Chang
    貢獻者: 老人服務事業管理系
    關鍵字: toluene diisocyanate
    skin absorption
    toluene diamine
    dermal exposure
    日期: 2008-03
    上傳時間: 2009-07-20 09:53:27 (UTC+8)
    摘要: Toluene diisocyanates (TDI) are commonly used in polyurethane (PU)-related products. TDIs have been documented as the leading cause of occupational asthma. Skin exposure to TDI in the workplace is common. However, no studies in the literature have investigated the exact biomarker concentration profile for skin TDI absorption through any in vivo animal studies. In this study a rat model was used to evaluate the TDI skin absorption to explore the doseresponse pattern and to determine the kinetic characteristics of urinary toluene diamine (U-TDA) during skin exposure. TDIs were topically exposed on the dorsum of rat skin at 0.2%, 1% and 5%. Consecutive urine samples were collected for 6 days and U-TDA were analysed using GC/ECD. It was demonstrated in this rat study that absorption of 2,4- and 2,6-TDI through skin contact is possible. A clear dose-dependent skin absorption relationship for 2,4- and 2,6-TDI was demonstrated by the AUC, C max findings and accumulative amounts (r ≥ 0.968). U-TDA concentration profiles in 6-day consecutive urine samples fit well in the first-order kinetics, although higher order kinetics could not be excluded for the high dose. The apparent half-lives for excretory urinary TDA were about 20 h consistent at various skin exposures. It is concluded that skin absorption of TDI was confirmed in a rat model and a clear dose-dependent skin absorption relationship for 2,4- and 2,6-TDI was demonstrated. Excretory U-TDA concentrations in 6-day consecutive urine samples via skin exposure reveal the first-order kinetics and the half-lives were about 20 h. Copyright © 2007 John Wiley & Sons, Ltd.
    显示于类别:[化妝品應用與管理系(所)] 期刊論文
    [老人服務事業管理系] 期刊論文


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