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    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/21321


    標題: Stability of Mometasone Furoate in a Cream Formulation
    Mometasone Furoate於乳膏中安定性之研究
    作者: Chun-Ren Chen
    K. C. Sung
    Jeng-Fen Huang
    Yi-Hsin Lin
    Su-Jong Chen
    貢獻者: 藥學系
    關鍵字: Mometasone Furoate
    Cream
    Stability
    Shelf life
    Mometasone Furoate
    乳膏
    安定性
    架儲期
    日期: 2004
    上傳時間: 2009-06-01 09:12:03 (UTC+8)
    摘要: Stability of 0.1% w/w mometasone furoate in a cream formulation in aluminum tubes or plastic bottles was studied. The samples were stored at 25±2℃/60±5%RH condition and assayed at three months intervals for one year for long term stability testing. The samples were also stored at 40±2℃/75±5%RH condition and assayed at two month intervals for six
    months for accelerated stability testing. A HPLC system with reverse phase column was used to assay the stability samples. The results were analyzed by the least squares linear regression and the lower 95% confidence intervals were also calculated. The shelf life of the cream formulation in either tubes or bottles is estimated over two years.
    本研究旨在探討Mometasone Furoate在塑膠瓶裝及鋁質軟管裝乳膏劑中之藥品安定性及其架儲期之研究。本研究將不同包裝之Mometasone Furoate儲存在25±2℃/60±5%RH環境下一年,並在每三個月取樣一次來分析其藥品含量以評估其長期安定性。此外,本研究也將不同包裝之Mometasone Furoate在40±2℃/75±5%RH環境下儲存
    6個月並每2個月取樣一次,以評估其加速安定性。所得到的含量數據以線性回歸及95%信賴區間之統計方式作分析,顯示Mometasone Furoate乳膏劑無論在塑膠瓶裝或鋁質管內皆具有超過兩年之藥品架儲期。
    關聯: 嘉南學報(科技類)30期:p.141-148
    Appears in Collections:[嘉南學報] 30 期 (2004)
    [藥學系(所)] 期刊論文

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