Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/21203
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 16704/19003 (88%)
Visitors : 5600666      Online Users : 75
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://ir.cnu.edu.tw/handle/310902800/21203


    Title: Effect of Welsh Onion Green Leave Juice on Hepatic Oxidative Stress in Spontaneously Hypertensive Rats
    青蔥綠葉汁對自發性高血壓大鼠肝臟氧化壓力之作用
    Authors: Bor-Sen Wang
    Zi-Yin Lin
    Jia-Huey Chen
    Jin-Jia Fan
    Contributors: 生活應用與保健系
    食品科技系
    Keywords: Welsh onion
    Antioxidant
    SHR
    iNOS
    青蔥
    抗氧化物
    自發性高血壓大鼠
    誘導型一氧化氮合成酶
    Date: 2005
    Issue Date: 2009-04-27 13:15:21 (UTC+8)
    Abstract: The antioxidant effects of Welsh onion green leaves were investigated in vivo. Earlier studies have demonstrated evidence about increased reactive oxygen species (ROS), enhanced inducible nitric oxide synthase (iNOS) expression, and elevated nitric oxide (NO) production in spontaneously hypertensive rats (SHR). In this study, SHR were fed with Welsh onion green leaves juice (WOG) (2 g/kg/day) for 28 days, and then the levels of oxidative damage and antioxidant enzyme activities in liver were compared between the fed and control animals. After SHR fed with WOG, the hepatic inducible nitric oxide synthase (iNOS) protein was markedly suppressed, and the hepatic glutathione level was increased by 12% and lipid peroxidation level was reduced by 22%. Though the activities of superoxide dismutase (SOD) were not changed significantly, the active glutathione (GSH) reductase was increased by 17% in WOG-fed SHR liver as compared with control group. These results indicate that WOG might play a protective role by decreasing iNOS expression and antioxidative effects in SHR liver.
    本實驗探討青蔥綠葉在體內之抗氧化作用。之前的研究已經證實在自發性高血壓大鼠體內有增加活性氧分子,加強誘導型一氧化氮合成酶表現,及增加一氧化氮自由基產生。在本實驗中,青蔥綠葉榨汁(2 g/kg/day)餵食自發性高血壓大鼠28天後,比較餵食組與控制組肝臟之氧化傷害程度及抗氧化酵素活性。結果顯示,自發性高血壓大鼠在餵食青蔥綠葉榨汁後,肝臟中誘導型一氧化氮合成酶表現明顯被抑制,同時,肝臟中GSH增加12%且脂質過氧化指標下降22%。雖然自發性高血壓大鼠在餵食青蔥綠葉榨汁後,superoxide dismutase活性並未明顯改變,但是GSH reductase活性增加17%。這些結果顯示青蔥綠葉榨汁可以藉由減少誘導型一氧化氮合成酶表現及抗氧化作用,而在自發性高血壓大鼠肝臟中扮演保護作用。
    Relation: 嘉南學報(科技類)31期:p.38-47
    Appears in Collections:[Chna Nan Annual Bulletin] No.31 2005
    [Dept. of Applied Life Science and Health] Periodical Articles
    [Dept. of Food Science & Technology] Periodical Articles

    Files in This Item:

    File Description SizeFormat
    v31_38_47.pdf241KbAdobe PDF616View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback