Chia Nan University of Pharmacy & Science Institutional Repository:Item 310902800/1815
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 18034/20233 (89%)
Visitors : 23365130      Online Users : 525
RC Version 7.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    CNU IR > Pharmacy and Science > Dept. of Pharmacy > MOST Project >  Item 310902800/1815
    Please use this identifier to cite or link to this item: https://ir.cnu.edu.tw/handle/310902800/1815


    Title: NALBUPHINE前驅藥微球粒劑型生體外及生體內的評估研究
    In vitro and in vivo Evaluation of Biodegradable Microspheres for Nalbuphine Prodrug Controlled Delivery
    Authors: 宋國峻
    Kuo-Chun Sung
    Contributors: 藥學系
    Keywords: 前驅藥
    微球粒
    體外評估
    體內評估
    藥物釋離
    Prodrug
    Microsphere
    in vitro evaluation
    in vivo evaluation
    Drug release
    Nalbuphine
    Date: 1998
    Issue Date: 2008-07-18 16:08:00 (UTC+8)
    Publisher: 台南縣:嘉南藥理科技大學藥學系
    Abstract: 本計畫主要目的在於開發一系列止痛藥物Nalbuphine前驅藥之Poly(lactide/glycolide)長效微球粒劑型及其生體外和生體內藥物釋放之評估研究。於生體外之藥物釋放實驗顯示不同比例之Lactide/glycolide高分子及不同親水性之前驅藥均對藥物釋放動力學有所影響。於體內之藥物動力學研究則顯示當Nalbuphine前驅藥親水性增加時其釋放速率將較快並較完全。對此系列Nalbuphine前驅藥而言,其微球粒製劑之生體外及生體內藥物釋放具有很好的相關性。
    The major purpose of this project is to develop and in vitro-in vivo evaluation of poly(lactide/glycolide) based microsphere for nalbuphine prodrug controlled delivery. The in vitro release studies showed that the different poly(lactide/glycolide) ratios and the different hydrophilic prodrugs both affect the kinetics of drug release. The in vivo release studies showed that the release of more hydrophilic prodrug is faster and more complete. A good correlation can be observed from the in vivo and in vitro release studies.
    Appears in Collections:[Dept. of Pharmacy] MOST Project

    Files in This Item:

    File Description SizeFormat
    NSC87-2314-B041-007.pdf188KbAdobe PDF664View/Open


    All items in CNU IR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback