DSpace collection: 2008第五屆海峽化學、生物及材料研討會
https://ir.cnu.edu.tw/handle/310902800/30467
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二氧化硅納米顆粒與碳黑納米顆粒紅外漫反射光譜的測量與分析
https://ir.cnu.edu.tw/handle/310902800/30522
title: 二氧化硅納米顆粒與碳黑納米顆粒紅外漫反射光譜的測量與分析 abstract: 用 FTIR-FTS3000光譜儀和漫反射附件分別採集了二氧化硅納米顆粒,碳黑納米顆粒和二氧化硅納米顆粒與碳黑納米顆粒的不同配比的混合樣品的紅外漫反射光譜。通過對測量結果的分析,發現二氧化硅納米顆粒的紅外漫反射光譜較之該物質的本體材料有藍移和寬化現象,此現象可以用納米粒子的小尺寸效應和量子尺寸來進行初步解釋。而碳黑納米顆粒因為其強吸光性的原因,實驗中沒有得到理想的光譜。混合樣品中,碳黑納米顆粒有一個最大吸收臨界濃度,此時二氧化硅納米顆粒與碳黑納米顆粒的質量比是100:20。在這個比例以內,碳黑納米顆粒的特徵峰位的F(R)函數與濃度符合朗伯-比爾定律。當碳黑納米顆粒在體系中的含量超過該比值時,隨著碳黑在體系中比例的增加,吸光度不再增大。本研究為該技術對此類材料在生物化學材料研究,無機礦物材料測試和工業流程檢測等方面提供了可供參考的基礎數據。
<br>Preparation and characterization of biodegradable acrylic acid grafted poly(ɛ-caprolactone)/chitosan blends
https://ir.cnu.edu.tw/handle/310902800/30521
title: Preparation and characterization of biodegradable acrylic acid grafted poly(ɛ-caprolactone)/chitosan blends abstract: The objective of this work was to study the effect of blending chitosan chitosan (CS) with poly ( ɛ-caprolactone) (PCL) and acrylic acid grafted PCL (PCLgAA) on their biomechanical properties. Blend films with different compositions were prepared from acetic acid in order to improve the properties of chitosan and obtain new fully biodegradable materials. The blends were characterized by Fourier transform infrared analysis (FTIR), differential scanning calorimetry (DSC), wide-angle x-ray diffraction (WAXD), and tensile tests. FTIR results showed that intermolecular hydrogen bonds existed between these components in the blends, and the hydrogen bonds were mainly between carbonyls of PCL and amino groups of chitosan. In addition, the amino groups were shown to form amide or imide linkage with the grafted carboxylic acid in PCLgAA. The melting temperatures, cold crystallization and crystallinity of the PCL component decreased with the increase in chitosan content. Blending chitosan with both PCL and PCLgAA suppressed the crystallization of the polymeric component. Although the crystal structure of PCL component was not changed, the crystallization of the blends was affected because of the existence of hydrogen bonds between two components, which was proved by WAXD results. Finally, the ductility of CS was improved during tensile testing when blended with both polymers.
<br>The Curative Effect of Astaxanthin on the Acetic Acid Gastric Ulcer
https://ir.cnu.edu.tw/handle/310902800/30520
title: The Curative Effect of Astaxanthin on the Acetic Acid Gastric Ulcer abstract: The pathological process of acetic acid gastric ulcer in rats is similar to that in human. The present study investigated the in vivo curative effect of astaxanthin against acetic acid induced gastric mucosal injury in rats. The rats were treated with acetic acid according to the method of painting acetic acid. The oral administration of astaxanthin (5,10 and 25mg/kg of body weight) showed significant curative effect on acetic acid gastric ulcer and inhibited elevation of the lipid peroxide level in gastric mucosa, and increase in the activity of radical scavenging enzymes such as superoxide dismutase, catalase and glutathione peroxides. A histological examination clearly indicated that the acute gastric mucosal lesion induced by acetic acid nearly disappeared after treated with astaxanthin.
<br>Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kB pathway
https://ir.cnu.edu.tw/handle/310902800/30519
title: Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kB pathway abstract: Background and Purpose: Tumor invasiveness and metastasis are characteristics of highly malignant cancers with poor clinical outcome. Tumor invasion is a perplexing cascade process involving a finely tuned interaction between cancer cells and various regulated factors. In this study, we first report the anti-invasive effect of ethylacetate extract from Antrodia cinnamomea (EAC) fruiting bodies in the human liver cancer cell line PLC/PRF/5.
Methods: Cell invasion assay. Electrophoretic mobility shift assay (EMSA) NF-κB reporter assay. MMP-2,MMP-9, and VEGF assay. Gelatin zymography. Western blot analysis. Matrigel plug angiogenesis assay. In vivo tumor model.
Results: Treatment with EAC decreased the cancer invasion of PLC/PRF/5 cells in a dose-dependent manner. This effect was strongly associated with a concomitant decrease in either the level or activity of VEGF,MMP-2,MMP-9 and MT1-MMP, and an increase in the expression of TIMP-1 and TIMP-2. EAC inhibited constitutively activated and inducible NF-κB in both its DNA-binding activity and transcriptional activity. Furthermore, EAC also inhibited the TNF-α-activated NF-κB –dependent reporter gene expression of MMP-9 and VEGF, and the invasion of cancer cells. EAC also exhibited an inhibitory effect on angiogenesis in a Matrigel Plug Angiogenesis Assay. Further investigation revealed that EAC’s inhibition of cancer cell growth and invasion was also evident in a nude mice model. Our results indicate that EAC inhibits the activation of NF-κB, and may provide a molecular basis for drug development using EAC as an anti-invasive agent in the prevention and treatment of cancer.
Conclusions: We have provided evidence demonstrating that EAC inhibits invasion and both MMPs and VEGF protein expression and enzyme activity. EAC suppresses invasion of PLC/PRF/5 cells by inhibition of NF-κB activity and sequentially reducing the expression and activity of MMP-9 in the cells. Therefore, we suggest that EAC could be potentially explored as a useful antiinvasive agent in the treatment of human liver carcinoma.
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