DSpace collection: 24 期 (1998)
https://ir.cnu.edu.tw/handle/310902800/22739
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Interaction Of Norfloxacin with Phospholipids in Liposomes and Their Stability
https://ir.cnu.edu.tw/handle/310902800/22766
title: Interaction Of Norfloxacin with Phospholipids in Liposomes and Their Stability abstract: Two perparation procedures were carried out to encapsulate norfloxacin into liposomes.The interaction of norfloxacin with phospholipids in liposomes was investigated by using differential scanning calorimetry and conformational analysis.The long term stability of liposomal drug was studied by measuring the leakage of norfloxacin at various storage conditions.These results indi-cated that,for liposomes prepared through the ethanol injection and freeze-drying processes,norfloxacin was not only encapsulated within the liposomes cavity but also bound to the lipid bilayer.Thus,the drug encapsulation inside liposomes was increased.For the long term stability,the results suggested that liposomes should be stored in the state of lyophilized powder at lower temperature and reconstitute by adding double-distilled before used.
<br>A Case Study on English Teachers Self-Introductions upon Meeting New Classes Using A Motivating Learning Activity
https://ir.cnu.edu.tw/handle/310902800/22765
title: A Case Study on English Teachers Self-Introductions upon Meeting New Classes Using A Motivating Learning Activity abstract: The purpose of this study is to illustrate the responses of the authors' 104 non-English major college students in two-year programs (both day and night school)toward a motivating learning activity based on teachers' self introductions in their first classes. The paper includes the motivations of the study, a description of the 15-20 minutes self-introduction, the method, and an evaluation of the results of the questionnaire given to the students based on the self-introduction. The questionnaire aims to reflect sutdents' responses in terms of their preferences, impressions and attention. Positive responses were found through the questionnaire after implementing the self-introduction activity. Despite the limitations of this preliminary study, such as its validity and reliability, it is hoped that the findings of this study and the authors' suggestions for successfully conducting this self-introduction activity will help English teachers break the ice with their students and, therefore, develop a highly motivating as well as happy learning environment on the first day of a new class.
<br>Use of Cremophor EL as a MDR Reversing Agent to Enhance Intestinal Absorption of Epirubicin in Everted Gut Sacs of Rats and Human Intestinal Epithelial Caco-2 Cell Layers
https://ir.cnu.edu.tw/handle/310902800/22764
title: Use of Cremophor EL as a MDR Reversing Agent to Enhance Intestinal Absorption of Epirubicin in Everted Gut Sacs of Rats and Human Intestinal Epithelial Caco-2 Cell Layers abstract: P-glycoprotein(P-gp) actively pumps out a number of anticncer drugs, such as epirubicin, from tumor cells.P-gp also expresses in the snall intestine at normal physiological conditions.Inhibition of instestinal P-gp function using MDR reversing agents may enhance oral bioavailabil-ity of some chemotherapeutic agents. Cremophor EL is a pharmacologically inert surfactant and has the advantage of no systemic side effect. Our previous flow cytometric study showed that Cremophor EL might have MDR reversing effects and increased the increased the intracellular accumulation of epirubicin in Caco-2 cells. In this study, the effect of Cremophor EL as a MDR reversing agent on the enhancement of intestinal absorption of epirubicin was investigated in both everted gut sacs of rats and human intestinal epithelial Caca-2 cell layers. The epirubicin concentrations measured in everted gut sacs pretreated with cremophor EL were significantly higher then those in epirubicin control for both the jejunum and the ileum. The addition of Cremophor EL significantly increased apical-to-basolateral permeability and reduced basolateral-to-apical permeability of epirubicin across Caca-2 cells. In conclusion, our results demonstrate that Cremophor EL is a potent MDR modifier of epirubicin in both human colon adenocarcinoma cells and everted gut sacs of rats at concentration that could be achieved in vivo. Use of Cremophor EL as excipient may increase intestinal absorption of some drugs through the mechanism of P-gp inhibition and thus improve drug bioavaiability for P-gp substrates.
<br>Short Proofs on The Connectivity of Graph
https://ir.cnu.edu.tw/handle/310902800/22763
title: Short Proofs on The Connectivity of Graph abstract: In this,we give two new and simple proofs relative to the connected graph.The relation-ship of connectivity and disjoint paths of any two points will be discussed,then a necessary condi-tion of n-connected graph presents next.
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