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Secondary metabolites of Neosartorya fischeri inhibited fibroblast-mediated tumorigenensis in triple-negative breast cancer
https://ir.cnu.edu.tw/handle/310902800/33676
title: Secondary metabolites of Neosartorya fischeri inhibited fibroblast-mediated tumorigenensis in triple-negative breast cancer abstract: Triple-negative breast cancer (TNBC), which is tested negative for estrogen receptor,progesterone receptor and HER2/neu receptor, is an aggressive histological subtype of breastcancer with limited choice of treatments. Epidermal growth factor receptor (EGFR) tyrosinekinase inhibitors (TKIs) have been studied to inhibit proliferation of TBNC, however, theylacked efficacy in clinical treatment. This may be due to cross-talk between cancer cells andneighboring stromal cells. For example, hepatocyte growth factor (HGF) secreted bycancer-associated fibroblasts has been shown to bind to a Met receptor and reduce efficiencyof TKIs in TNBC, indicating that microenvironment affected development of cancer cells. Tosurvey the effective TNBC inhibitors, we established a soft agar colony formation system forbreast cancer MDA-MB-468 cells with co-culture of fibroblasts. Neosartorya fischeri extractswere tested for their inhibitory activity on TNBC by applying to this system. The resultsshowed that some secondary metabolites of Neosartorya fischeri inhibitedfibroblast-mediated colony formation of MDA-MB-468 cells. One of these metabolitesexhibited inhibitory effect on phosphorylation of EGFR and Met, which offered the potentialas a chemotherapeutic agent for TNBC.
<br>Development of Astaxanthin loaded Solid lipid nanoparticles (SLNs) versus nanostructured lipid carriers (NLCs) for dermal delivery
https://ir.cnu.edu.tw/handle/310902800/33654
title: Development of Astaxanthin loaded Solid lipid nanoparticles (SLNs) versus nanostructured lipid carriers (NLCs) for dermal delivery abstract: The aim of this study was to develop and assess nanostructured lipid carriers (NLC)compared to solid lipid nanoparticles (SLN) encapsulated with Astaxanthin. The purpose ofthe present research was to avoid oxidation and degradation of the active ingredient thenprolonged storage. In the this study, Encapsulation of Astaxanthin in SLN(Astaxnthin-SLN)and NLC(Astaxnthin-NLC) were prepared by high pressure homogenizers technique (500bars 5cycles). The experimental results show that SLN and NLC particle were around120nm-170nm with a narrow distribution and a stable zeta potential were around-25mV~-41mV. For all tested the total recovery of formulations were more than 90% and theencapsulation efficiency was 100%.We used Cetyl palmitate、Caprylic/Capric Triglycerideand Alkyl polyglucoside (APG) were prepared NLC ,that had better stability and lessdegradation than SLN. After storage for 3 months at 45℃, Astaxnthin-NLC were a moststable formulations that total recovery were more than 90% ,and by the skin irritation testresult was After storage for 3 months at 45℃,Astaxnthin-NLC were a most stableformulations that total recovery were more than 90% ,and by the skin irritation test result waslow irritation. The NLC has a characteristic of Occlusion effect, so we applied the serumcontaining NLC(S-NLC) on the face. The number of test 10 people and results showed that70% of people improved in moisture (P<0.05). The in vitro percutaneous absorption ofFranz cell results showed that Emulsion containing NLC(E-NLC) transdermal permeation ofAstaxanthin was greater than traditional-emulsion(T-emulsion), they were significantincreased (P < 0.05). These findings indicated that NLC could add to the traditional emulsionto improve the skin penetration.
<br>l,4-benzodiazepin-2,5-dione 化合物合成及其物化性質探討
https://ir.cnu.edu.tw/handle/310902800/33644
title: l,4-benzodiazepin-2,5-dione 化合物合成及其物化性質探討 abstract: l,4-benzodiazepin-2,5-dione 化合物是具有較為廣泛的生物活性,也是重要的藥效基團。本研究以isatoic anhydride 為起始物,以醋酸為溶劑,與不同的胺基酸在100℃下反應8 小時,即可經由一個合成步驟獲得一系列 l,4-benzodiazepin-2,5-dione 的衍生物。其次,在抗氧化能力的評估上,利用螯合亞鐵離子實驗,測試benzodiazepin 衍生物結構對亞鐵離子螯合能力的影響。Keywords: l,4-benzodiazepin-2,5-dione、胺基酸、二胜?
<br>Calcium chloride 添加量對 Sodium Alginate/Aspirin/Calcium chloride/Polyglutamic acid 藥物
https://ir.cnu.edu.tw/handle/310902800/33639
title: Calcium chloride 添加量對 Sodium Alginate/Aspirin/Calcium chloride/Polyglutamic acid 藥物 abstract: 本研究將不同比例之阿斯匹靈(Asp) / 聚麩胺酸(γ-PGA) /海藻酸鈉(SA),加入不同濃度的氯化鈣溶液中,是為了獲得不同特性的顆粒,如顆粒大小、比表面積、表面型態、藥物包埋率,進而影響藥物的釋放擴散及釋放速率。本實驗原理為氯化鈣溶液中的鈣離子(Ca2+)會取代鈉離子(Na+)的角色,並且抓住海藻酸鈉分子間的羧酸離子,使得分子間的聯結性更強,利用此交聯作用(cross-linking)可使分子更為固定,並降低其流動性來形成顆粒。
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